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Concurrently, immune dysregulation has been identified as a common feature in individuals with ASD, with studies demonstrating a strong association between immune dysfunction and the severity of behavioral symptoms ( + monocytes isolated from ASD patients led to significantly elevated expression of TNF-, IL-1, and IL-6 ( 4 Gut microbiota and neurodevelopmental disorders 4.1 Gut microbes linked to neurodevelopment The gut microbiota critically regulates brain activity and behavioral processes, a mechanism largely mediated by the gut-brain axis, a bidirectional signaling pathway connecting the gastrointestinal tract and the central nervous system, as evidenced by extensive scientific inquiry (Vuong et al., 2020)

But injectable B12 might be needed for severe cases or when absorption is a problem

Thyroid eye disease, teprotumumab, and hearing loss: An evolving role for otolaryngologists